ATPase



ATPase is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions. Vacuolar-type H+ ATPase (V-ATPase) couples the energy to proton transport across membranes. The images at the left and at the right correspond to one representative ATPase, i.e. the NMR structure of rat ATPase (1mo8).

3D Structures of ATPase
Update June 2011

Cu transporting ATPase
2kmv, 2kmx, 2arf – hATPase NBD – human – NMR

2kij - hATPase MBD – NMR

1yjr, 1yjt, 1yju, 1yjv - hATPase (mutant) 6th soluble domain – NMR

1y3j, 1y3k - hATPase 5th soluble domain – NMR

1s6o, 1s6u - hATPase 2nd soluble domain – NMR

1q8l - hATPase 2nd MBD  – NMR

1aw0, 2aw0 - hATPase 4th MBD  – NMR

1kvi, 1kvj - hATPase 1st MBD  – NMR

3dxs - AtATPase MBD – Arabidopsis thaliana

2k1r - hATPase MBD+ ATOX1 – NMR

2rop, 2g9o, 2ga7 - hATPase MBD – NMR

2rml - BsATPase N-terminal – Bacillus subtilis – NMR

2gcf - sATPase N-terminal - Synechocystis – NMR

2iye - ATPase catalytic fragment – Sulfolobus solfataricus

1fvq, 1fvs - hATPase – NMR

3cjk – hATPase + Cu transporting protein ATX1

Na/K transporting ATPase
3a3y - SaATPase+K+ouabain – Squalus acanthias

3kdp, 3b8e – pATPase – pig

3n23 – pATPase + ouabain

3b8e - pATPase a+BeF3

2hc8 –AfATPase CopA A domain

2b8e - AfATPase CopA NBD

2xze - SaATPase

1mo8, 1mo7 - ATPase α-1 – rat

1q3i - pATPase NBD

Ca transporting ATPase
3fgo - rATPase+CPA+AMPPCP – rabbit

3b9r, 1xp5 - rATPase+AlF4

1wpg - rATPase+MgF4

2zbe, 3b9b – rATPase+BeF3

2zbf - rATPase+BeF3+TG

2zbg - rATPase+AlF4+TG

2zbd, 3ar8 - rATPase+AlF4+nucleotide+Ca

3ar9 - rATPase+BeF3+nucleotide

2dqs, 3ar2, 1vfp - rATPase+AMPPCP

2c88, 2c8k, 3ar4, 3ar3, 3ar5, 3ar7 - rATPase+nucleotide+TG

2ear, 2c8l - rATPase+TG

1iwo - rATPase

2agv - rATPase+TG+BHQ

2eas - rATPase+CPA

2eat - rATPase+CPA+GT

3ar6 - rATPase+TNP-ADP+GT

2eau - rATPase+CPA+curcumin

3ba6 - rATPase phosphoenzyme intermediate

3fpb - rATPase+ATP+cyclopiazonic acid

3fps, 2oa0 - rATPase+ADP+cyclopiazonic acid

2o9j - rATPase+MgF4+cyclopiazonic acid

1kju - rATPase E2 state

2c9m - rATPase Ca2E1 state

1t5s - rATPase Ca2E1 state+AMPPCP

1t5t - rATPase Ca2E1 state+ADP+AlF4

1su4 - rATPase +2Ca2

2by4 - rATPase HNE2 state+thapsigargin derivative

Zn transporting ATPase
2ofg, 2ofh - sATPase N-terminal – NMR

K+ transporting ATPase
2a00, 2a29 - EcATPase NBD of KdpB+AMPPNP– Escherichia coli – NMR

1svj, 1u7q - EcATPase NBD of KdpB – NMR

As+ transporting ATPase
1ii0, 1f48 - EcATPase

1ihu – EcATPase+Mg+ADP+AlF3

1ii9 - EcATPase+AMPPNP

3h84, 3idq – yATPase GET3 – yeast

3ibg - ATPase GET3 – Aspergillus fumigatus

H+ transporting ATPase
3b8c - AtATPase C terminal truncated

1mhs - ATPase – Neurospora crassa

Na+ transporting ATPase
2db4 - ATPase subunit K – Enterococcus hirae

1yce - ATPase rotor ring – Ilyobacter tartaricus

H/K transporting ATPase
1iwc, 1iwf - pATPase NBD

3ixz - pATPase a+AlF4

2xzb – pATPase subunits α, β

Mg++ transporting ATPase
3gwi – EcATPase P-1 NBD

Arg/ornithine transporting ATPase
3md0 – MtATPase+GDP – Mycobacterium tuberculosis

1kmh - ATPase alpha subunit+tentoxin – spinach

1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow

1h8h - cATPase+ AMPPNP

1efr - cATPase+efrapeptin

3fks – ATPase – yeast

3ea0 – ATPase ParA, fragment – Chlorobium tepidum

2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi

3cf0, 3cf1, 3cf3 – mATPase NBD+ADP – mouse

3cf2 - mATPase NBD+ADP+AMP-PNP

2r31, 2p4x – PdATPase ATP12 – Paracoccus denitrificans

2zd2 – PdATPase (mutant) ATP12

1d8s – EcATPase F1

1vdz – PhATPase subunit A – Pyrococcus horikoshii

P-ATPase Cu transporting
3a1c – AfATPase + AMPPCP

3a1d - AfATPase + ADP-Mg 3a1e - AfATPase (mutant) + AMPPCP

RNA-dependent ATPase
3eaq, 3i31, 3i32 – TtATPase fragment

3mwj – TtATPase N-terminal (mutant)

3mwk, 3nbf – TtATPase N-terminal + 8-oxo-AMP

3mwl - TtATPase N-terminal (mutant) + 8-oxoadenine

3nej - TtATPase reca-like domain (mutant)

Proteasome-associated ATPase
3fp9, 3m9b, 3m9h – MtATPase intern domain

3m91, 3m9d - MtATPase coiled coil domain + protein PUP

Transitional endoplasmic reticulum ATPase
3hu1, 3hu2, 3hu3 – hTer-ATPase + ATPGS

LAO/AO transport system ATPase
3nxs – ATPase – Mycobacterium smegmatis